This level of cooperation is necessary to meet the dramatic increases in
performance required for emerging genomics and proteomics applications at
affordable prices, and brings together the capabilities of three leaders in the
fields of bioinformatics, high performance computing, and massively parallel
systems. Proteomics is the study of the function, structure and interactions of
proteins in cells, including humans and other organisms.
"The key aspect of this relationship is the simultaneous provision of
algorithmic support, design of actual application software, and development of
the system platform by three organizations with world-class competence in their
respective areas," said Bill Blake, Vice President of High Performance Technical
Computing at Compaq. "This effort is a direct response to the challenge by
Celera's president, J. Craig Venter, who said that even the most powerful of
today's supercomputers do not meet the needs of his company's work in the
genomic era. Our intent with this alliance is to apply the same full system
modeling approach to bioscience that has been so successfully applied to
physical sciences in the DOE/NNSA Stockpile Stewardship program."
J. Craig Venter, Celera's president and chief scientific officer, said, "Just
three years ago, the computational needs of biology were thought to be minor and
irrelevant to the computing industry. Today, biologists are setting the pace of
development for the industry. At Celera, we take pride in excelling in the
application of computers to biology and the new era in medicine that is
developing as a result. As Compaq and the Department of Energy move toward
creation of the next generation of supercomputers for defense purposes, we look
forward to helping both groups develop the new machines, software and algorithms
to advance life sciences."
Said Bill Camp, Sandia director of computation, computers and mathematics,
"Delivering affordable and scalable computer architectures is the foundation of
modern supercomputing and has been the focus of Sandia research for more than a
decade. Our knowledge will be useful because understanding the complexity of the
human genome requires manipulating ever vaster amounts of information, using
more advanced computing technologies than was required even for the assembly of
the human genome itself. So we view this relationship as strategic for our
continuing missions as a DOE/NNSA national security laboratory, look forward to
providing world-class expertise in parallel algorithms and systems software in
the cause of human health, and welcome the opportunity to play a role in
developing what may be some of the most exciting science in recent human
history."
The alliance will use Compaq Alpha processors connected in massively parallel
configuration with extremely high bandwidth, and low latency mesh interconnects.
Compaq and Sandia will collaborate on the development of system hardware and
software. Both have extensive experience with supercomputers based on Alpha.
The alliance will focus on future generations of the AlphaServer SC series, and
the goal is to create a prototype in the 2004 time frame.
Celera and Sandia will concentrate on creation of advanced algorithms for
biology research, and on new visualization technologies for analyzing the
massive quantities of experimental data from high-throughput instruments.
All three groups will contribute to integrating the system hardware and software
and on optimizing performance.
Driving the design for this next-generation supercomputer are anticipated
computational and data management requirements for proteomics. These
requirements are expected to be vastly more complicated than the pattern
recognition and assembly operations required to sequence the human genome.
Researchers are counting on proteomics to take advantage of genomic databases in
developing new medicines, crops, materials and solutions to challenges in energy
development and environmental cleanup.