Virtual Biopsy, a new way to look at cancer

Columbus 27 May 2003Scientists are using new imaging technology to help them perform "virtual biopsies", biological profiles of specific tumours that may help predict a patient's response to treatment and probability of long-term survival. This whole new realm of imaging is called functional magnetic resonance imaging (MRI), a process that offers insight into a tumour's character, not just its superficial structure.

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Using functional MRI, Dr. Michael Knopp, a radiologist and a member of the Ohio State University Comprehensive Cancer Center's Experimental Therapeutics Programme, is studying breast, prostate, pancreatic tumours and others to see if some of their particular biological quirks are related to response to treatment and survival.

Dr. Knopp noted that while X-rays can reveal information about a tumour's size and shape, that information alone is not enough to help physicians plan and tailor some of the newest treatments. "It's not what we see, but what we don't that may be more important."

What X-rays don't show, but what functional MRI does, according to Dr. Knopp, includes biological processes like angiogenesis, or blood vessel growth surrounding a tumour. Using MRI and special contrast agents, Dr. Knopp is able to determine the permeability, or "leakiness" of the tumour's support system. Early studies suggest the "leakier" the vessels, the more likely a patient will respond to treatment. "Functional MRI allows us to measure permeability; understanding that characteristic alone can help clinicians better manage the patient's care", Dr. Knopp explained.

Functional MRI can also reveal a tumour's interior landscape, or its heterogeneity. Dr. Knopp stated that some tumours are extremely heterogeneous, meaning they are not biologically uniform. Instead, many may contain clusters of "hot spots", clumps of cells that are biologically different and often resistant to treatment. "Functional MRI can help us identify those areas, understand their particular features, and hopefully, design targeted therapies for those specific sites", as Dr. Knopp stated.

In functional MRI, images are made by measuring minute radio waves produced when hydrogen atoms in the body are trapped and vibrate within a magnetic field. The varying intensity of the signal reveals structural features and biological patterns illuminated by injected contrast agents.

"Analysing data from those images can help us literally see where some chemotherapies are effective, and others are not. We know, for example, that in many cases, treatment with chemotherapy may kill 70 or 80 percent of a cancer, but the other tumour cells remain problematic. Now, we can find out exactly where those resistant areas are and we can be more selective and precise with additional treatment", stated Dr. Knopp.

While functional MRI offers new ways to visualise cancer at work, it presents several problems that need to be solved before it becomes routinely useful in clinical care. It is still so new that scientists have yet to agree on a standard methodology they will use to visualise what they want to see. That makes comparing studies and findings across multiple centres difficult. In addition, one study alone can generate as many as 700 to 800 images that need to be synthesised and read collectively for a complete analysis, a process requiring substantial computational power and highly-trained specialists.

"It's an emerging field, and we think we are just beginning to see what it can do", concluded Dr. Knopp. He reviewed functional MRI in oncology in an article in the April issue of Molecular Cancer Therapeutics. His research is supported by the National Cancer Institute and the Ohio Biomedical Research and Technology Transfer Fund.


Leslie Versweyveld

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