"Centralized image access, review and analysis have the potential to substantially reduce the amount of resources and time required to perform image evaluation for a variety of clinical trials", stated Eliot Siegel, M.D., Professor of Diagnostic Radiology at the University of Maryland - In Vivo Imaging Workspace, part of NCI's cancer Biomedical Informatics Grid (caBIG). "This represents an exciting addition to the NCIA."
Cedara's imaging service Grid is a set of imaging functions, such as complex 2D rendering and 3D imaging running on server computers, that reduces the need for expensive and complex hardware for workstations and networks comprising an advanced imaging solution. The imaging service Grid is configured as a scalable 64-bit back-end solution that is integrated directly with the archive component from NCIA. The Grid can be deployed as a standalone server that serves images to several clients - or scaled to a "server-farm" deployment that can serve images to hundreds of clients, as well as support load-balancing of these clients. It also can be connected and serve images to any viewer.
The I-Response viewer establishes an HTTP request with the imaging service Gid and allows users to employ measurement tools found in I-Response on the selected studies. This distributed processing viewer contains image analysis tools that enable researchers to evaluate and quantify images obtained during clinical trials. I-Response supports multiple modalities and operates with imaging equipment from different manufacturers.
Key clinical features include:
- The ability to track and compare standard criteria for tumour assessment including the Response Evaluation Criteria in Solid Tumours Group (RECIST) as well as the World Health Organization (WHO).
- Measurements in 2D and MPR.
- Ability to calculate volume-based measurements.
- Ability to calculate PET SUV values.
- Advanced semi-automatic segmentation tools for quickly identifying lesions, and work flow to support transitions to the next slices.
- Results of the 2D and MPR measurements can be saved and retrieved for subsequent review. The XML schema will be publishable for use within the NCI caBIG Imaging Workspace projects.
- Double Blind Reading work flow that facilitates collection and display of measurements based on clinical roles - e.g. Reader 1, Reader 2, Adjudicator.
- Other functionality that facilitates work flow includes quick access to measurement report tables, thick slice review, linked scroll and identification of target and non-target tumours.