Language centres revealed and brain surgery refined with new mapping

San Francisco 02 January 2008Neurosurgeons from the University of California, San Francisco (UCSF) are reporting significant results of a new brain mapping technique that allows for the safe removal of tumours near language pathways in the brain. The technique minimizes brain exposure and reduces the amount of time a patient must be awake during surgery.


Perhaps even more profound, the study provides new data that refines scientists' understanding of how language is organized within the human cortex. It identifies new regions involved in speech production, reading and naming. The team used this data to generate a three-dimensional cortical language map that is more detailed and integrates more data than any language map of the brain ever generated.

"This study represents a paradigm shift in language mapping during brain tumour resection", stated senior author Mitchel Berger, MD, professor and chairman of the UCSF Department of Neurological Surgery and director of the UCSF Brain Tumour Research Center. "Not only have we proven this technique can be safely relied upon for brain tumour resection, we have shown functional language organisation to be much more diverse and individualized than previously thought."

"Accurately understanding cortical language organisation has clinical implications for more than just brain tumour patients", stated lead author Nader Sanai, MD, senior resident in neurological surgery at UCSF. "Any patient with a seizure-disorder, stroke or head injury who has language-related difficulties can now be better understood in the context of this revised anatomy."

The findings are presented in the January 3, 2008 issue of The New England Journal of Medicine. The technique, which Mitchel Berger and his team helped pioneer, is known as "negative brain mapping". It eliminates neurosurgeons' dependence on traditional language mapping methods that typically require the removal of large sections of skull and extensive brain mapping while the patient is awake. It also allows for smaller craniotomies that expose only the tumour and a small margin of surrounding brain tissue, rather than several centimeters or more of the patient's brain.

After the craniotomy, the neurosurgeon "maps" the brain by stimulating a section - 1 cm by 1 cm - at a time with a bipolar electrode. The strategy does not require positive identification of language sites - defined as an arrest in speech, inability to name objects or read, or difficulty in articulating words, as in traditional brain mapping, but rather is driven by localization of negative sites - areas that contain no language function.

"Nearly half our patients had no positive language sites in the area exposed, yet their functional outcomes remained nearly identical or better than patients who underwent extensive positive language mapping", stated Nader Sanai. "In addition, our results show that negative language mapping can be relied upon even when language function is already affected by tumour growth."

Language mapping, originally created to help guide epilepsy surgery, has proved to be an essential tool in helping neurosurgeons identify which parts of the tumour can be safely removed and in protecting patients from damage to speech and language centres, according to Mitchel Berger. This is the largest study of its kind to show that this technique can be further refined for brain tumour resection without harming the patient.

The language map generated during the study shows that areas processing language function in the brain are widely distributed, sometimes varying in location by as much as several centimeters from patient to patient. This has implications for language organisation models, which are currently based on the assumption that specific language functions have fixed anatomical locations.

Over eight years, Mitchel Berger and his team tested negative language mapping on a total of 250 consecutive patients - 146 men and 104 women, all of whom had gliomas - a common and often fatal brain tumour - affecting the dominant hemisphere of their brain.

One week following surgery, 194 of the 250 patients - 77,6 percent - retained the language function they had prior to surgery. Six months later, only four of the 243 surviving patients - 1,6 percent - exhibited worsened language function. Cumulatively, the neurosurgeons stimulated 3281 cortical sites in the brains of the 250 patients.

"The map we have generated addresses the critical question of how cortical language sites for motor speech, naming and reading are distributed within the dominant hemisphere of the human brain", added Nader Sanai. "It represents a comprehensive set of language co-ordinates that will serve as a guide for neurosurgeons to plan operations more safely and effectively."

It is estimated that 20.500 men and women will be diagnosed with, and 12.740 men and women will have died of, cancer of the brain and other areas of the nervous system in 2007, according to the American Cancer Society. The neurosurgeons were not involved in any relationships with companies that make products related to this study and they received no funding.

UCSF Medical Center's neurology and neurosurgery programmes are ranked among the top five in the nation by U.S. News & World Report. UCSF's neurologists and neurosurgeons work closely with colleagues and scientists across multiple disciplines to develop and apply new and novel treatments for patients with brain disorders in the Bay Area, across the nation and the world. UCSF is a leading university dedicated to defining health worldwide through advanced biomedical research, graduate level education in the life sciences and health professions, and excellence in patient care.

Leslie Versweyveld

[Medical IT News][Calendar][Virtual Medical Worlds Community][News on Advanced IT]