Computer game could assist breathing of COPD patients

Chicago 15 April 2008Patients suffering from chronic obstructive pulmonary disease (COPD) may gain better control over their breathing by using their breath to play a computer game. The computer game may help these COPD patients breathe more efficiently, especially during exercise, according to a new study performed by researchers at the Veterans Administration and the University of Illinois at Chicago (UIC).


"COPD is a double-edged sword: the incapacitating lung condition can cause such serious shortness of breath that every-day physical activity, such as walking a flight of stairs, becomes unduly burdensome - and yet one of the few effective symptomatic treatments for COPD is the very thing that its victims dread most: exercise", stated leading researcher Eileen G. Collins, Ph.D., of the Edward Hines Jr. VA Hospital in Hines, Illinois and UIC. "This computerized programme is still in the research stages, but shows promise for future use in pulmonary rehabilitation programmes."

The results of this randomized, controlled study appeared in the April 15 issue of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society. COPD is the fourth leading cause of death in the United States and causes serious, long-term disability, according to the American Lung Association. More than 12 million people are currently diagnosed with COPD, and an additional 12 million likely have the disease but are unaware of it.

COPD patients with the greatest disability are also those most likely to be unable to exercise long enough to reap the benefits rehabilitation can offer them. "One of the key mechanisms of shortness of breath and exercise impairment in these patients", Dr. Collins stated, "is their inability to fully exhale air when active." This phenomenon causes trapping of air in the lungs - i.e., dynamic hyperinflation - and diminishes the patient's breathing efficiency.

Dr. Collins and colleagues designed a randomized, controlled trial, the first of its kind, to test whether this computer programme could decrease the extent of air trapping during exercise and thus improve the results of rehabilitation in COPD patients. "Our primary goal was to determine if patients with COPD would achieve longer exercise duration if they were engaged in ventilation feedback, in addition to the regular exercise programme over either ventilation feedback or exercise alone", stated Dr. Collins.

A total of 64 patients were randomized to three groups - exercise alone, exercise plus ventilation feedback (VF) or VF alone. While exercising on a stationary bicycle or treadmill, patients in the ventilation feedback group had their breathing monitored by a computer programme which provided them with real-time biofeedback and set individualized goals, presented graphically on a screen in front of them. Patients could see their current speed and depth of breathing in relation to the set goal, encouraging them to inhale more slowly and exhale more completely in order to achieve the goal.

At baseline, the groups all performed similarly in exercise tolerance tests. Comparing all the groups, those that underwent a regimen of exercise and ventilation feedback showed significant improvements in exercise duration, and those who underwent exercise alone fared much better than those who only received ventilation feedback. Because of the multiple comparisons between groups, the exercise-plus-ventilation feedback group did not attain statistically significant improvements over the exercise-only group, but the results indicated a strong trend in that direction. Exercise-induced hyperinflation was also reduced in patients randomized to exercise-plus-ventilation feedback over either programme by itself. Duration of exercise tolerance in the exercise-plus-ventilation feedback group also showed a significant trend toward improvement.

If patients can be taught to translate these breathing techniques from the computer game to activities of daily living, they could potentially greatly improve their quality of life. "We are conducting a follow-up clinical trial to compare computerized breathing feedback with other unique methods of pulmonary rehabilitation", stated Dr. Collins.

The study was funded by the United States Department of Veterans Affairs, Rehabilitation Research & Development.

Leslie Versweyveld

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